Revenue Recognition - Summarize Activity of the Net Product Revenue Allowance and Reserve Categories (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	$ 190,824	$ 128,557
Provision related to current period sales	852,420	822,813
Provision related to prior period sales	(2,034)	(3,872)
Credits/payments made for current period sales	(583,437)	(637,999)
Credits/payments made for prior period sales	(175,547)	(118,675)
Ending balance	282,226	190,824
Trade Allowances
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	36,242	29,261
Provision related to current period sales	121,378	132,881
Credits/payments made for current period sales	(36,473)	(96,834)
Credits/payments made for prior period sales	(34,511)	(29,066)
Ending balance	86,636	36,242
Rebates, Chargebacks and Discounts
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	141,200	90,997
Provision related to current period sales	684,010	621,937
Provision related to prior period sales	(2,034)	(3,872)
Credits/payments made for current period sales	(504,210)	(482,254)
Credits/payments made for prior period sales	(134,210)	(85,608)
Ending balance	184,756	141,200
Product Returns
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	7,798	4,579
Provision related to current period sales	1,531	3,543
Credits/payments made for prior period sales	(1,240)	(324)
Ending balance	8,089	7,798
Other Incentives
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	5,584	3,720
Provision related to current period sales	45,501	64,452
Credits/payments made for current period sales	(42,754)	(58,911)
Credits/payments made for prior period sales	(5,586)	(3,677)
Ending balance	$ 2,745	$ 5,584