Co-Promotion Agreement - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2018	Dec. 31, 2020
Co Promotion Agreement [Line Items]
Accrued expenses and other current liabilities	$ 253,111		$ 198,641
Co-Promotion Agreement | Kowa Pharmaceuticals America, Inc.
Co Promotion Agreement [Line Items]
Promotion fee as a percentage of gross margin		18.50%
Maximum co-promotion tail payments receive period	3 years
Co-promotion tail payments payable		$ 17,800
Accrued co- promotion tail payments		$ 16,600
Accrued expenses and other liabilities			3,800
Accrued expenses and other current liabilities	$ 600		$ 3,200