Income Taxes - Income Taxes Effect of Each Type of Temporary Difference Comprising Net Differed Tax Asset (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Deferred tax assets:
Net operating losses	$ 127,378	$ 125,859
Stock-based compensation	8,563	7,565
Tax credits	15,803	14,690
Lease Liability	2,348	2,219
Other reserves and accrued liabilities	11,257	14,702
Gross deferred tax assets	165,349	165,035
Less: valuation allowance	(160,295)	(160,841)	$ (137,976)
Total deferred tax assets	5,054	4,194
Deferred tax liabilities:
Depreciation and amortization	(3,404)	(2,399)
Lease Asset	(1,639)	(1,784)
Other liabilities	(11)	(11)
Total deferred tax liabilities	$ (5,054)	$ (4,194)