Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)	$ 7,729	$ (18,000)	$ (22,645)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Depreciation and amortization	587	597	180
Amortization of investments	1,929	1,602
Stock-based compensation	36,938	45,813	30,917
Amortization of debt discount and debt issuance costs		635	1,644
Amortization of intangible asset	2,270	1,441	679
Changes in assets and liabilities:
Accounts receivable, net	(9,079)	(38,144)	(49,907)
Inventory	(167,066)	(112,095)	(18,967)
Prepaid and other current assets	8,595	(17,636)	(10,366)
Other long-term assets	(24)	642	(900)
Interest receivable	738	(1,329)
Accrued interest payable		(428)	(210)
Deferred revenue	(1,923)	(2,214)	136
Accounts payable, accrued expenses and other current liabilities	51,516	114,741	65,913
Other long-term liabilities	1,253	2,629	(5,840)
Net cash used in operating activities	(66,537)	(21,746)	(9,366)
CASH FLOWS FROM INVESTING ACTIVITIES:
Sale and maturities of securities	394,294	301,989
Purchases of securities	(290,195)	(678,700)
Disposal (purchase) of furniture, fixtures and equipment	4	(252)	(2,478)
Net cash provided by (used in) investing activities	104,103	(376,963)	(2,478)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net of transaction costs			440,108
Proceeds from issuance of common stock under employee stock purchase plan	1,650	1,957	2,165
Proceeds from exercise of stock options, net of transaction costs	2,921	5,158	24,478
Payment of transaction costs for conversion of preferred stock		(504)
Payment on debt from royalty-bearing instrument		(50,336)	(31,652)
Taxes related to stock-based awards	(9,644)	(15,182)	(25,487)
Net cash (used in) provided by financing activities	(5,073)	(58,907)	409,612
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH	32,493	(457,616)	397,768
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD	190,879	648,495	250,727
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD	223,372	190,879	648,495
Cash received (paid) during the year for:
Interest		(2,043)	(4,591)
Income taxes	3,656	(207)	(67)
Supplemental disclosure of non-cash transactions:
Laxdale milestone	$ 12,000		8,457
Initial recognition of operating lease right-of-use asset			$ 8,995
Conversion of Series A Convertible Preferred Stock into common stock		$ 18,020