Equity - Incentive Equity Awards - Summary of Equity Awards Activity (Detail) - USD ($)		12 Months Ended
		Dec. 31, 2021	Dec. 31, 2020
Stockholders Equity Note [Line Items]
Common shares issued for stock option exercises		1,203,845	1,623,460
Gross and net proceeds from stock option exercises		$ 2,921,000	$ 5,158,000
Restricted Stock Units (RSUs)
Stockholders Equity Note [Line Items]
Common shares issued in settlement of RSUs and Performance Based RSUs vested		2,133,328	1,267,164
Shares retained for settlement of employee tax obligations		782,917	461,143
Performance-Based RSUs
Stockholders Equity Note [Line Items]
Common shares issued in settlement of RSUs and Performance Based RSUs vested	[1]	1,923,316	1,240,584
Shares retained for settlement of employee tax obligations		816,931	514,784

[1] Performance-based RSUs vested in connection with the achievement of certain regulatory and sales performance conditions associated with the REDUCE-IT clinical trial and subsequent revenue growth. These performance-based RSUs have fully vested as of August 2021.