Commitments and Contingencies - Additional Information (Detail) $ in Thousands	Dec. 31, 2021 USD ($)	Dec. 31, 2021 GBP (£)	Dec. 31, 2020 USD ($)
Commitments And Contingencies Disclosure [Line Items]
Potential payable amount over the agreement terms based on minimum purchase obligation	$ 196,100
Communication costs related to direct-to-consumer activities	300
Accrued expenses and other current liabilities	253,111		$ 198,641
Further Indication for AMR101 | Marketing Approval In Europe
Commitments And Contingencies Disclosure [Line Items]
Potential aggregate stock or cash payment | £		£ 7,500,000
Accrued expenses and other current liabilities	12,000
Further Indication for AMR101 | Potential Marketing Approval 1
Commitments And Contingencies Disclosure [Line Items]
Aggregate stock or cash payment upon potential market approval	6,800	5,000,000.0
Further Indication for AMR101 | Potential Marketing Approval 2
Commitments And Contingencies Disclosure [Line Items]
Aggregate stock or cash payment upon potential market approval	$ 6,800	£ 5,000,000.0