Debt - Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) - USD ($)		12 Months Ended
	Dec. 06, 2012	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Debt Disclosure [Line Items]
Outstanding debt		$ 0
Interest expense, non-cash			$ 635,000	$ 1,644,000
CPPIB
Debt Disclosure [Line Items]
Repayment of debt		150,000,000.0
BioPharma Debt
Debt Disclosure [Line Items]
Amount received at the closing of the agreement	$ 100,000,000.0
Maximum repayment of future revenue and receivables	$ 150,000,000.0
Royalty-Bearing Debt | Cash
Debt Disclosure [Line Items]
Interest expense, contractual coupon interest		0	1,600,000
Royalty-Bearing Debt | Non Cash
Debt Disclosure [Line Items]
Interest expense, non-cash		$ 0	$ 600,000