Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Total revenue, net	$ 583,187	$ 614,060	$ 429,755
Less: Cost of goods sold	121,327	131,444	96,019
Gross margin	461,860	482,616	333,736
Operating expenses:
Selling, general and administrative	408,334	463,312	323,623
Research and development	29,307	38,959	34,392
Restructuring	13,717
Total operating expenses	451,358	502,271	358,015
Operating income (loss)	10,502	(19,655)	(24,279)
Interest income	1,220	4,901	8,499
Interest expense	(129)	(2,605)	(6,626)
Other (expense) income, net	(302)	104	(75)
Income (Loss) from operations before taxes	11,291	(17,255)	(22,481)
Provision for income taxes	(3,562)	(745)	(164)
Net income (loss)	$ 7,729	$ (18,000)	$ (22,645)
Earnings (loss) per share:
Basic	$ 0.02	$ (0.05)	$ (0.07)
Diluted	$ 0.02	$ (0.05)	$ (0.07)
Weighted average shares outstanding:
Basic	395,992	381,759	342,538
Diluted	402,480	381,759	342,538
Product Revenue, Net
Total revenue, net	$ 580,320	$ 607,025	$ 427,391
Licensing and Royalty Revenue
Total revenue, net	$ 2,867	$ 7,035	$ 2,364