X0303 4 2008-10-28 0 0000897075 REPROS THERAPEUTICS INC. RPRX 0001350855 Efficacy Capital, Ltd. 11622 EL CAMINO REAL SUITE 100 SAN DIEGO CA 92130 0 0 1 0 0001366073 Efficacy Biotech Fund L.P. 11622 EL CAMINO REAL SUITE 100 SAN DIEGO CA 92130 0 0 1 0 0001366071 Efficacy Biotech Fund LTD 11622 EL CAMINO REAL SUITE 100 SAN DIEGO CA 92130 0 0 1 0 0001366070 Efficacy Biotech Master Fund Ltd. 11622 EL CAMINO REAL SUITE 100 SAN DIEGO CA 92130 0 0 1 0 0001366074 Lappe Mark 11622 EL CAMINO REAL SUITE 100 SAN DIEGO CA 92130 0 0 1 0 0001366268 Kayyem Jon Faiz 11622 EL CAMINO REAL SUITE 100 SAN DIEGO CA 92130 0 0 1 0 Common Stock 2008-10-28 4 P 0 9892 6.87 A 4256436 I See Footnotes Common Stock 2008-10-29 4 P 0 24400 6.97 A 4280836 I See Footnotes The shares are held by investment funds. Includes 3,958,936 shares held by Efficacy Biotech Master Fund, Ltd., a Bermuda Exempted Mutual Fund Company and 321,900 shares held by FMG Special Opportunity Fund. The Reporting Persons act as investment advisors with investment and voting discretion over portfolio investments. The Reporting Persons are indirect owners of the reported securities. Exhibit List Exhibit 99 - Joint Filer Information Efficacy Capital Ltd., by Mark Lappe, Managing Partner 2008-10-30