Exhibit 22.1

Subsidiary Guarantors

As of March 31, 2024, each of the following subsidiaries of Enbridge Inc. (“Enbridge”), both of which are indirect, wholly-owned subsidiaries of Enbridge, has fully and unconditionally guaranteed on an unsecured, joint and several basis, each of the registered debt securities of the Company listed below:

Subsidiary Guarantors

1.Spectra Energy Partners, LP, a Delaware limited partnership

2.Enbridge Energy Partners, L.P., a Delaware limited partnership

Registered Debt Securities of Enbridge Guaranteed by each of the Subsidiary Guarantors

1.3.500% Senior Notes due 2024

2.2.500% Senior Notes due 2025

3.2.500% Senior Notes due 2025

4.4.250% Senior Notes due 2026

5.1.600% Senior Notes due 2026

6.5.900% Senior Notes due 2026

7.3.700% Senior Notes due 2027

8.6.000% Senior Notes due 2028

9.3.125% Senior Notes due 2029

10.6.200% Senior Notes due 2030

11.2.500% Sustainability-Linked Senior Notes due 2033

12.5.700% Sustainability-Linked Senior Notes due 2033

13.4.500% Senior Notes due 2044

14.5.500% Senior Notes due 2046

15.4.000% Senior Notes due 2049

16.3.400% Senior Notes due 2051

17.6.700% Senior Notes due 2053