Exhibit 22.1

Subsidiary Guarantors

As of September 30, 2023, each of the following subsidiaries of Enbridge Inc. (“Enbridge”), both of which are indirect, wholly-owned subsidiaries of Enbridge, has fully and unconditionally guaranteed on an unsecured, joint and several basis, each of the registered debt securities of the Company listed below:

Subsidiary Guarantors

1.Spectra Energy Partners, LP, a Delaware limited partnership

2.Enbridge Energy Partners, L.P., a Delaware limited partnership

Registered Debt Securities of Enbridge Guaranteed by each of the Subsidiary Guarantors

1.0.550% Senior Notes due 2023

2.4.000% Senior Notes due 2023

3.Floating Rate Senior Notes due 2024

4.3.500% Senior Notes due 2024

5.2.150% Senior Notes due 2024

6.2.500% Senior Notes due 2025

7.2.500% Senior Notes due 2025

8.4.250% Senior Notes due 2026

9.1.600% Senior Notes due 2026

10.5.969% Senior Notes due 2026

11.3.700% Senior Notes due 2027

12.3.125% Senior Notes due 2029

13.2.500% Sustainability-Linked Senior Notes due 2033

14.5.700% Sustainability-Linked Senior Notes due 2033

15.4.500% Senior Notes due 2044

16.5.500% Senior Notes due 2046

17.4.000% Senior Notes due 2049

18.3.400% Senior Notes due 2051