Exhibit 22.1

Subsidiary Guarantors

As of June 30, 2022, each of the following subsidiaries of Enbridge Inc. (“Enbridge”), both of which are indirect, wholly-owned subsidiaries of Enbridge, has fully and unconditionally guaranteed on an unsecured, joint and several basis, each of the registered debt securities of the Company listed below:

Subsidiary Guarantors

1.Spectra Energy Partners, LP, a Delaware limited partnership

2.Enbridge Energy Partners, L.P., a Delaware limited partnership

Registered Debt Securities of Enbridge Guaranteed by each of the Subsidiary Guarantors

1.2.900% Senior Notes due 2022

2.Floating Rate Senior Notes due 2023

3.0.550% Senior Notes due 2023

4.4.000% Senior Notes due 2023

5.Floating Rate Senior Notes due 2024

6.3.500% Senior Notes due 2024

7.2.150% Senior Notes due 2024

8.2.500% Senior Notes due 2025

9.2.500% Senior Notes due 2025

10.4.250% Senior Notes due 2026

11.1.600% Senior Notes due 2026

12.3.700% Senior Notes due 2027

13.3.125% Senior Notes due 2029

14.2.500% Sustainability-Linked Senior Notes due 2033

15.4.500% Senior Notes due 2044

16.5.500% Senior Notes due 2046

17.4.000% Senior Notes due 2049

18.3.400% Senior Notes due 2051