Exhibit 22.1

Subsidiary Guarantors

As of September 30, 2021, each of the following subsidiaries of Enbridge Inc. (“Enbridge”), both of which are indirect, wholly-owned subsidiaries of Enbridge, has fully and unconditionally guaranteed on an unsecured, joint and several basis, each of the registered debt securities of the Company listed below:

Subsidiary Guarantors

1.Spectra Energy Partners, LP, a Delaware limited partnership

2.Enbridge Energy Partners, L.P., a Delaware limited partnership

Registered Debt Securities of Enbridge Guaranteed by each of the Subsidiary Guarantors

1.Floating Rate Senior Notes due 2022

2.2.900% Senior Notes due 2022

3.Floating Rate Senior Notes due 2023

4.4.000% Senior Notes due 2023

5.3.500% Senior Notes due 2024

6.2.500% Senior Notes due 2025

7.4.250% Senior Notes due 2026

8.3.700% Senior Notes due 2027

9.3.125% Senior Notes due 2029

10.2.500% Sustainability-Linked Senior Notes due 2033

11.4.500% Senior Notes due 2044

12.5.500% Senior Notes due 2046

13.4.000% Senior Notes due 2049

14.3.400% Senior Notes due 2051