Exhibit 22.1

Subsidiary Guarantors

As of December 31, 2020, each of the following subsidiaries of Enbridge Inc. (“Enbridge”), both of which are indirect, wholly-owned subsidiaries of Enbridge, has fully and unconditionally guaranteed on an unsecured, joint and several basis, each of the registered debt securities of the Company listed below:

Subsidiary Guarantors

1.Spectra Energy Partners, LP, a Delaware limited partnership

2.Enbridge Energy Partners, L.P., a Delaware limited partnership

Registered Debt Securities of Enbridge Guaranteed by each of the Subsidiary Guarantors

1.Floating Rate Note due 2022

2.2.900% Senior Notes due 2022

3.4.000% Senior Notes due 2023

4.3.500% Senior Notes due 2024

5.2.500% Senior Notes due 2025

6.4.250% Senior Notes due 2026

7.3.700% Senior Notes due 2027

8.3.125% Senior Notes due 2029

9.4.500% Senior Notes due 2044

10.5.500% Senior Notes due 2046

11.4.000% Senior Notes due 2049