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Stockholders' Equity (Tables)
12 Months Ended
Dec. 31, 2019
Equity [Abstract]  
Summary of Significant Weighted Average Assumptions Used for Estimating Fair Value Under Stock Option Plans
The following are the significant weighted average assumptions used for estimating the fair value under our stock option plans:
   
2019
   
2018
  
2017
 
Per share fair value at grant date
   —     $1.45   —   
Risk free interest rate
   —      3.0  —   
Expected volatility
   —      224.  —   
Dividend yield
   —      0  —   
Expected life in years
   —      4.0   —   
Summary of Stock Option Transactions under Stock Option Plan
Option activity during the three years ended December 31, 2019 was as follows:
 
   
Number of Shares
   
Weighted
Average
Exercise Price
 
Outstanding at December 31, 2016
   13,116   $360.30 
Granted
        
Canceled
   (503   45.10 
Exercised
        
  
 
 
   
 
 
 
Outstanding at December 31, 2017
   12,613    370.30 
Granted
   128,000    1.92 
Canceled
   (290   4,723.90 
Exercised
        
  
 
 
   
 
 
 
Outstanding at December 31, 2018
   140,323    25.29 
Granted
        
Canceled
   (3,067   29.11 
Exercised
        
  
 
 
   
 
 
 
Outstanding at December 31, 2019
   137,256   $25.20 
  
 
 
   
 
 
Summary of Currently Outstanding and Exercisable Stock Options
The following table summarizes information concerning currently outstanding and exercisable stock options at December 31,
2019
:
 
            
Exercisable
 
Range of
Exercise Prices
  
Number
Outstanding
  
Weighted
Average
Remaining
Contractual
Life in Years
  
Weighted
Average
Exercise Price
  
Number
Exercisable
   
Weighted
Average
Exercise
Price
 
 
$1.92 – $1.92
   125,500   8.8  $1.92   62,750   $1.92 
 33.00 – 33.00   4,867   5.9   33.00   4,867    33.00 
 318.00 – 318.00   6,217   3.9   318.00   6,217    318.00 
 378.00 – 2,844.00   610   3.1   1,289.50   610    1,289.50 
 
$3,150.00 – $5,148.00
   62   0.5   4,722.63   62    4,722.63 
 
 
 
  
 
 
  
 
 
  
 
 
   
 
 
 
  137,256   8.4  $25.20   74,507   $44.81 
 
 
 
    
 
 
   
Summary of Weighted-Average Grant Date Fair Value of Restricted Stock Awards
The weighted-average grant date fair value of our restricted stock awards, their total fair value and the fair value of all shares that have vested during each of the past three years is as follows:
 
   
Year ended December 31
 
   
2019
   
2018
   
2017
 
Weight-average grant date fair value
   —      —     $10.70 
Fair value of restricted stock awards granted
   —      —     $48,000 
Fair value of restricted stock awards vested
   —      —     $23,000 
Summary of Outstanding Warrants
The following is a summary of outstanding warrants at December 31, 2019:
 
   
            Common Shares
 
   
Total
   
Currently
Exercisable
   
Price per
Share
   
Expiration Date
 
Warrants related to February 2015 agreement
   306    306   $450.45    February 13, 2020 
Warrants related to March 2015 financing
   10,209    10,209   $244.88    September 24, 2020 
Warrants related to March 2015 financing
   1,021    1,021   $306.09    March 20, 2020 
Warrants related to October 2015 financing
   135,517    135,517   $60.00    October 14, 2020 
Warrants related to October 2015 financing
   9,034    9,034   $65.63    October 14, 2020 
Warrants related to August 2016 financing
   53,506    53,506   $30.00    February 2, 2022 
Warrants related to August 2016 financing
   4,994    4,994   $38.55    August 2, 2021 
Warrants related to December 2016 financing
   685,667    685,667   $20.00    December 14, 2021 
Warrants related to March 2018 financing
   158,100    158,100   $11.40    September 9, 2023 
Warrants related to March 2018 financing
   11,067    11,067   $15.80    March 6, 2023 
Warrants related to July 2018 financing
   2,571,429    2,571,429   $3.50    July 25, 2023 
Warrants related to July 2018 financing
   154,286    154,286   $4.38    July 25, 2023 
Warrants related to May 2019 financing
   119,000    119,000   $1.25    May 23, 2024 
Warrants related to October 2019 financing
   11,438,716    11,438,716   $0.25    October 10, 2024 
Warrants related to October 2019 financing
   828,380    —     $0.31    October 8, 2024