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Unaudited Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES          
Net loss $ (5,023) $ (10,019) $ (20,916) $ (30,447)  
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation for property, plant and equipment     567 393  
Amortization of intangible assets     965 1,009  
Reduction in the carrying amount of the right-of-use assets     890 1,031  
Loss on disposal of property, plant and equipment       65  
Stock-based compensation expense     5,591 5,059  
Acquired in-process research and development       6,555  
Change in fair value of investments (696) 3,687 2,012 205  
Impairment loss of long-term investments       865  
Government grant as a result of loan forgiveness       (472)  
Changes in operating assets and liabilities:          
Accounts receivable     (2,757) (773)  
Inventories     (3,866) (371)  
Prepaid expenses and other assets     (238) (539)  
Accounts payable     (1,073) 26  
Accrued and other current liabilities and other liabilities     (1,376) (1,770)  
Deferred income     (44) (37)  
Net cash used in operating activities     (20,245) (19,201)  
CASH FLOWS FROM INVESTING ACTIVITIES          
Proceeds from disposal of property and equipment     138 10  
Purchases of property, plant and equipment     (2,186) (3,730)  
Receipt in advance from sales of equity investment in Juventas     16,921    
Cash paid to acquire in-process research and development       (6,555)  
Receipt of repayment of Black Belt Convertible note       172  
Net cash provided by/(used in) investing activities     13,205 (15,950)  
CASH FLOWS FROM FINANCING ACTIVITIES          
Proceeds from bank borrowings     4,001 709  
Repayment of bank borrowings     (1,001) (463)  
Repurchase of common stock     (3,000)    
Stock issuance costs       (2,019)  
Proceeds from sale of common stock       32,500  
Net cash provided by financing activities       30,727  
Effect of exchange rate change on cash and cash equivalents     (2,422) 486  
Net decrease in cash and cash equivalents     (9,462) (3,938)  
Cash, cash equivalents and restricted cash at beginning of period     38,704 57,064 $ 57,064
Cash, cash equivalents and restricted cash at end of period 29,242 53,126 29,242 53,126 38,704
Non-cash investing and financing activities:          
Purchases of property, plant and equipment in accrued and other current liabilities     3,111 2,680  
Cash and cash equivalents 26,742 53,126 26,742 53,126 38,704
Restricted cash 2,500   2,500    
Total cash, cash equivalents and restricted cash shown in the statement of cash flows $ 29,242 $ 53,126 29,242 53,126 $ 38,704
Black Belt Tx Limited          
CASH FLOWS FROM INVESTING ACTIVITIES          
Cash paid to acquire convertible loan       (86)  
Alesta Tx          
CASH FLOWS FROM INVESTING ACTIVITIES          
Cash paid to acquire convertible loan       (261)  
Cleave Therapeutics, Inc          
CASH FLOWS FROM INVESTING ACTIVITIES          
Cash paid to acquire convertible loan       $ (5,500)  
BioInvent International AB          
CASH FLOWS FROM INVESTING ACTIVITIES          
Proceeds from sales of equity securities     1,294    
Precision Autoimmune Therapeutics Co., Ltd          
CASH FLOWS FROM INVESTING ACTIVITIES          
Cash paid to acquire equity investment     $ (2,962)