UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 12b-25
                           NOTIFICATION OF LATE FILING

                                                        SEC FILE NUMBER: 1-12471
                                                     CUSIP NUMBER: [458124 10 8]

|X| Form 10-K |_| Form 20-F |_| Form 11-K |_| Form 10-Q |_| Form N-SAR
|_| Form N-CSR
                       For Period Ended: December 31, 2007

     |_|  Transition Report on Form 10-K     |_|  Transition Report on Form 20-F
     |_|  Transition Report on Form 11-K     |_|  Transition Report on Form 10-Q
     |_|  Transition Report on Form N-SAR

    Nothing in this form shall be construed to imply that the Commission has
                   verified any information contained herein.

If the notification  relates to a portion of the filing checked above,  identify
the Item(s) to which the notification relates: Not applicable

PART I - REGISTRANT INFORMATION

Full Name of Registrant: Integrated Surgical Systems, Inc.

Former Name if Applicable: Not Applicable

Address of Principal Executive Office: 1433 N. Market Blvd. Suite 1, Sacramento,
CA 95834

PART II - RULES 12b-25(b) AND (c)

If the subject report could not be filed without  unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed.

            (a)   The reasons described in reasonable detail in Part III of this
                  form could not be eliminated  without  unreasonable  effort or
                  expense;

            (b)   The subject  annual  report,  semi-annual  report,  transition
                  report on Form 10-K,  Form 20-F, Form 11-K, Form N-SAR or Form
                  N-CSR,  or  portion  thereof,  will be filed on or before  the
|X|               fifteenth  calendar day following the  prescribed due date; or
                  the  subject  quarterly  report or  transition  report on Form
                  10-Q, or subject  distribution report on Form 10-D, or portion
                  thereof  will be filed on or  before  the fifth  calendar  day
                  following the prescribed due date; and

            (c)   The  accountant's  statement or other exhibit required by Rule
                  12b-25(c) has been attached if applicable.

PART III - NARRATIVE

State below in reasonable  detail the reasons why Forms 10-K,  20-F, 11-K, 10-Q,
N-SAR,  N-CSR or the transition  report or portion  thereof,  could not be filed
within the prescribed period.



      The  Registrant  is unable to timely file its Annual Report on Form 10-KSB
      for the year  ended  December  31,  2007  without  unreasonable  effort or
      expense as a result of the failure of the  Registrant's  certified  public
      accountant  to timely  complete  its review and audit of the  Registrant's
      financial statements.

PART IV - OTHER INFORMATION

(1)   Name  and  telephone  number  of  person  to  contact  in  regard  to this
      notification:

                Charles J. Novak             (916)                 285-9943
                ----------------             -----                 --------
                (Name)                    (Area Code)         (Telephone Number)

(2)   Have all other periodic  reports required under Section 13 or 15(d) of the
      Securities  Exchange Act of 1934 or Section 30 of the  Investment  Company
      Act of 1940 during the preceding 12 months or for such shorter period that
      the registrant  was required to file such report(s) been filed?  If answer
      is no, identify report(s).

            |X| Yes |_| No

(3)   Is it  anticipated  that any  significant  change in results of operations
      from the  corresponding  period for the last fiscal year will be reflected
      by the earnings statements to be included in the subject report or portion
      thereof?

            |X| Yes |_| No

      If so, attach an explanation of the anticipated  change,  both narratively
      and  quantitatively,   and,  if  appropriate,  state  the  reasons  why  a
      reasonable estimate of the results cannot be made.

See attachment.


                                       2


      Integrated  Surgical  Systems,  Inc.  has caused this  notification  to be
signed on its behalf by the undersigned thereunto duly authorized.

Date: April 1, 2008                  Integrated Surgical Systems, Inc.



                                     By: /s/ Peter B. Mills
                                         ---------------------------------------
                                         Peter B. Mills, Chief Executive Officer


                                       3


                            Attachment to Form 12b-25
                            -------------------------

Part IV - Other Information, Item (3)

For the year ended  December 31, 2007,  the  Registrant's  results of operations
reflected net income of  approximately  $4.9 million as compared with net income
for the year ended December 31, 2006 of approximately $1.6 million. The increase
in net income in 2007 of  approximately  $3.3 million is  attributable to income
from   discontinued   operations   principally   arising  out  of  the  sale  of
substantially all of the Registrant's assets in June 2007.