UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 12b-25
                           NOTIFICATION OF LATE FILING

                                                      SEC FILE NUMBER: 1-12471
                                                      CUSIP NUMBER: 458124 10

   [  ] Form 10-K     [   ] Form 20-F     [   ] Form 11-K     [ X ] Form 10-Q
   [  ] Form 10-D     [   ] Form N-SAR    [   ] Form N-CSR

                        For Period Ended: March 31, 2005

[   ] Transition Report on Form 10-K     [   ] Transition Report on Form 20-F
[   ] Transition Report on Form 11-K     [   ] Transition Report on Form 10-Q
[   ]       Transition Report on Form N-SAR

                        For the Transition Period Ended:

     Nothing in this form shall be construed to imply that the Commission has
verified any information contained herein.

     If the notification relates to a portion of the filing checked above,
identify the Item(s) to which the notification relates: Not applicable

PART I - REGISTRANT INFORMATION

Full Name of Registrant:  Integrated Surgical Systems, Inc.

Former Name if Applicable:  Not Applicable

Address of Principal Executive Office:
                  1850 Research Drive, Davis, California 95616

PART II - RULES 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed.

[X]  (a)  The reasons described in reasonable detail in Part III of this form
          could not be eliminated without unreasonable effort or expense;

     (b)  The subject annual report, semi-annual report, transition report on
          Form 10-K, Form 20-F, Form 11-K, Form N-SAR or Form N-CSR, or portion
          thereof, will be filed on or before the fifteenth calendar day
          following the prescribed due date; or the subject quarterly report or
          transition report on Form 10-Q or subject distribution report on Form
          10-D, or portion thereof, will be filed on or before the fifth
          calendar day following the prescribed due date; and

     (c)  The accountant's statement or other exhibit required by Rule 12b-25(c)
          has been attached if applicable.

PART III - NARRATIVE

State below in reasonable detail the reasons why Forms 10-K, 20-F, 11-K, 10-Q,
10-D, N-SAR , N-CSR or the transition report or portion thereof, could not be
filed within the prescribed period.

     The registrant has significantly reduced its workforce in order to conserve
     funds as it seeks equity and/or debt financing. The unavailability of staff
     and the need to obtain equity and/or debt financing has required the
     registrant's executive officer and employees to devote substantial effort
     and expense which otherwise would have been devoted to the preparation and
     filing of the registrant's Quarterly Report on Form 10-QSB for the quarter
     ended March 31, 2005. For such reason, the subject Form 10-QSB could not be
     filed within the prescribed period.




PART IV - OTHER INFORMATION

(1)    Name and telephone number of person to contact in regard to this
       notification: Charles J. Novak, Chief Financial Officer: (530) 792-2600

(2)    Have all other periodic reports required under Section 13 or 15(d) of the
       Securities Exchange Act of 1934 or Section 30 of the Investment Company
       Act of 1940 during the preceding 12 months or for such shorter period
       that the registrant was required to file such report(s) been filed? If
       the answer is no, identify report(s).
                                                [X] Yes     [   ] No

(3)    Is it anticipated that any significant change in results of operations
       from the corresponding period for the last fiscal year will be reflected
       by the earnings statements to be included in the subject report or
       portion thereof?
                                                [X] Yes     [   ] No
       If so, attach an explanation of the anticipated change, both narratively
       and quantitatively, and, if appropriate, state the reasons why a
       reasonable estimate of the results cannot be made.

       The registrant anticipates reporting net income of approximately $1.0
       million on net sales of $1.8 million for the quarter ended March 31,
       2005, compared to a net loss of $256,637 on net revenues of $782,801 for
       the quarter ended March 31, 2004.


Integrated Surgical Systems, Inc. has caused this notification to be signed on
its behalf by the undersigned thereunto duly authorized.


Date: May 17, 2005                       Integrated Surgical Systems, Inc.


                                         By:    /s/ Charles J. Novak
                                                --------------------------------
                                                Charles J. Novak
                                                Chief Financial Officer