X0201 4 2004-04-21 0 0000893160 VENTANA MEDICAL SYSTEMS INC VMSI 0001134554 MASSARANY HANY 1910 INNOVATION PARK DR TUCSON AZ 85737 0 1 0 0 Sr. Vice President, Global Ops Common Stock 2004-04-21 4 S 0 2736 49 D 612 D Common Stock 2004-04-21 4 M 0 10000 49.005 D 612 D Common Stock 2004-04-21 4 M 0 2125 49.005 D 612 D Common Stock 2004-04-21 4 M 0 1610 49.005 D 612 D Common Stock 2004-04-21 4 M 0 4682 49.005 D 612 D Common Stock 2004-04-21 4 M 0 1930 49.005 D 612 D Common Stock 2004-04-21 4 M 0 568 49.005 D 612 D Common Stock 2004-04-22 4 M 0 7493 49 D 612 D Stock Options (Right to Buy) 17.5 2004-04-21 4 M 0 10000 17.5 D 2009-05-06 Common Stock 10000 10000 D Stock Options (Right to Buy) 23.5 2004-04-21 4 M 0 2125 23.5 D 2010-01-01 Common Stock 2125 375 D Stock Options (Right to Buy) 23.5 2004-04-21 4 M 0 1610 23.5 D 2000-01-24 2010-01-24 Common Stock 1610 0 D Stock Options (Right to Buy) 21.25 2004-04-21 4 M 0 4682 21.25 D 2001-01-22 2011-01-22 Common Stock 4682 0 D Stock Options (Right to Buy) 20.12 2004-04-21 4 M 0 1930 20.12 D 2012-01-22 Common Stock 1930 0 D Stock Options (Right to Buy) 20.24 2004-04-21 4 M 0 568 20.24 D 2003-01-27 2013-01-27 Common Stock 568 7493 D Stock Options (Right to Buy) 20.24 2004-04-22 4 M 0 7493 20.24 D 2003-01-27 2013-01-27 Common Stock 7493 0 D Stock options vest 20% on 5/6/00 and 1/60th of the shares vest the last day of each month thereafter with full vesting on 5/6/04. Stock options vest 20% on 1/1/01 and 1/60th of the shares vest the last day of each month thereafter with full vesting on 1/1/05. Stock options vest 20% on 1/22/03 and 1/60th of the shares vest the last day of each month thereafter with full vesting on 1/22/07. Nicholas Malden as attorney in fact for Hany Massarany 2004-04-23