X0202 4 2008-02-19 1 0000893160 VENTANA MEDICAL SYSTEMS INC VMSI 0001134554 MASSARANY HANY 1910 INNOVATION PARK DR TUCSON AZ 85755 0 1 0 0 Chief Operating Officer Common Stock 2008-02-19 4 D 0 15000 89.5 D 37 D Common Stock 2008-02-19 4 D 0 37 89.5 D 0 D Stock Options (Right to Buy) 22.365 2008-02-19 4 D 0 8000 67.135 D 2004-01-26 2014-01-26 Common Stock 8000 0 D Stock Options (Right to Buy) 40.25 2008-02-19 4 D 0 2450 49.25 D 2007-02-28 2017-02-28 Common Stock 2450 0 D Stock Options (Right to Buy) 40.25 2008-02-19 4 D 0 32666 49.25 D 2007-02-28 2017-02-28 Common Stock 32666 0 D Disposed of pursuant to merger agreement between issuer and Roche in exchange for a cash payment of $89.50 per share. This option, which vested 20% after 12 months and 1/60th each month thereafter commencing on January 26, 2004, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes. This option, which provided for monthly vesting beginning March 28, 2007, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes. Leslie Oaks Attorney in Fact for Hany Massarany 2008-02-20