X0202 4/A 2006-06-14 2006-06-16 0000892112 SIRNA THERAPEUTICS INC RNAI 0001239242 ROBERTS BRYAN E C/O VENROCK ASSOCIATES 2494 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 1 0 0 0 Non-Qualified Stock Option (Right to Buy) 4.71 2006-06-14 4 A 0 22292 A 2006-06-14 2016-06-13 Common Stock 22292 22292 D This amendment is being filed solely to reflect an additional stock option grant to purchase shares of Common Stock which was inadvertently omitted in the Form 4 filed on June 16, 2006. Grant to Reporting Person of Non-Qualified Stock Option to purchase 12,738 shares of Common Stock in lieu of annual retainer, at the Reporting Person's election, in accordance with the Issuer's 2005 Performance Incentive Plan and of Non-Qualified Stock Option to purchase 9,554 shares of Common Stock in lieu of a chairperson retainer, at the Reporting Person's election, in accordance with the Issuer's 2005 Amended Director Compensation Plan. The options were fully-vested and exercisable on the date of grant. Not applicable. Bryan E. Roberts 2006-06-19