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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Nj8lW6ae7TllhbZIFDzwYN7DrtrOvtL+EljLZkFdnrqy6jDo61+zl/cX5rDqO18P
 +deWg8Y/Eu/P3/8IF8oR/A==

<SEC-DOCUMENT>0001179110-05-014773.txt : 20050725
<SEC-HEADER>0001179110-05-014773.hdr.sgml : 20050725
<ACCEPTANCE-DATETIME>20050725170420
ACCESSION NUMBER:		0001179110-05-014773
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050721
FILED AS OF DATE:		20050725
DATE AS OF CHANGE:		20050725

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TAPESTRY PHARMACEUTICALS, INC
		CENTRAL INDEX KEY:			0000891504
		STANDARD INDUSTRIAL CLASSIFICATION:	MEDICINAL CHEMICALS & BOTANICAL PRODUCTS [2833]
		IRS NUMBER:				841187753
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		4840 PEARL EAST CIRCLE
		STREET 2:		SUITE 300W
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		303-516-8500

	MAIL ADDRESS:	
		STREET 1:		4840 PEARL EAST CIRCLE
		STREET 2:		SUITE 300W
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NAPRO BIOTHERAPEUTICS INC
		DATE OF NAME CHANGE:	19940421

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			HAYES ARTHUR HULL JR
		CENTRAL INDEX KEY:			0001267713

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-24320
		FILM NUMBER:		05971916

	BUSINESS ADDRESS:	
		STREET 1:		4840 PEARL EAST CIRCLE
		STREET 2:		SUITE 300W
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		303-516-8500

	MAIL ADDRESS:	
		STREET 1:		C/O TAPESTRY PHARMACEUTICALS, INC
		STREET 2:		4840 PEARL EAST CIRCLE SUITE 300W
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-07-21</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000891504</issuerCik>
        <issuerName>TAPESTRY PHARMACEUTICALS, INC</issuerName>
        <issuerTradingSymbol>TPPH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001267713</rptOwnerCik>
            <rptOwnerName>HAYES ARTHUR HULL JR</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>4840 PEARL EAST CIRCLE, SUITE 300W</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Options (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.54</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-07-21</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>7500</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2006-07-21</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-07-21</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>7500</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7500</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Grant to Reporting Person of a non-statutory stock option under the Issuer's 2004 Non-Employee Directors' Stock Option Plan, as a result of his appointment as a member of the Research and Development Committee of the Board of Directors.  The option fully vests on July 21, 2006 and expires on July 21, 2015, unless it expires sooner pursuant to the terms of the Plan.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Kai P. Larson as Attorney in Fact under Power of Attorney given by Reporting Person</signatureName>
        <signatureDate>2005-07-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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