-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 RByiCukATjLg2TPzyHHlrxHUawh+TG1Nolxds8uTzBoCrJcQr9dWnrLNCSst2q7T
 8cKCkHHBgvE7pwP2u4ujzQ==

<SEC-DOCUMENT>0001179110-05-014677.txt : 20050722
<SEC-HEADER>0001179110-05-014677.hdr.sgml : 20050722
<ACCEPTANCE-DATETIME>20050722181403
ACCESSION NUMBER:		0001179110-05-014677
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050721
FILED AS OF DATE:		20050722
DATE AS OF CHANGE:		20050722

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GOULD GEORGE M
		CENTRAL INDEX KEY:			0001242115

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-24320
		FILM NUMBER:		05969958

	MAIL ADDRESS:	
		STREET 1:		C/O PROTINE DESIGN LAB
		STREET 2:		34801 CAMPUS DR
		CITY:			FREEMONT
		STATE:			CA
		ZIP:			94555

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TAPESTRY PHARMACEUTICALS, INC
		CENTRAL INDEX KEY:			0000891504
		STANDARD INDUSTRIAL CLASSIFICATION:	MEDICINAL CHEMICALS & BOTANICAL PRODUCTS [2833]
		IRS NUMBER:				841187753
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		4840 PEARL EAST CIRCLE
		STREET 2:		SUITE 300W
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		303-516-8500

	MAIL ADDRESS:	
		STREET 1:		4840 PEARL EAST CIRCLE
		STREET 2:		SUITE 300W
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NAPRO BIOTHERAPEUTICS INC
		DATE OF NAME CHANGE:	19940421
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-07-21</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000891504</issuerCik>
        <issuerName>TAPESTRY PHARMACEUTICALS, INC</issuerName>
        <issuerTradingSymbol>TPPH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001242115</rptOwnerCik>
            <rptOwnerName>GOULD GEORGE M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>4840 PEARL EAST CIRCLE, SUITE 300W</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Options (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.54</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-07-21</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>10000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2006-07-21</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-07-21</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>10000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>10000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Grant to Reporting Person of a non-statutory stock option under the Issuer's 2004 Non-Employee Directors' Stock Option Plan, as a result of his reappointment as Chairman of the Nominating and Corporate Governance Committee of the Board of Directors.  The option fully vests on July 21, 2006 and expires on July 21, 2015, unless it expires sooner pursuant to the terms of the Plan.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Kai P. Larson as Attorney in Fact under Power of Attorney given by George M. Gould, Reporting Person</signatureName>
        <signatureDate>2005-07-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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