Condensed Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Revenues:
Product sales, net	$ 1,148	$ 306	$ 2,416	$ 1,432
License and contract revenue	195		338
Total revenues	1,343	306	2,754	1,432
Operating costs and expenses:
Cost of product sold	202	36	347	91
Research and development	14,017	8,020	26,196	16,375
Selling, general and administrative	13,792	10,102	30,542	21,245
Settlement expense				95
Total operating costs and expenses	28,011	18,158	57,085	37,806
Loss from operations	(26,668)	(17,852)	(54,331)	(36,374)
Other income (expense):
Interest expense	(467)	(316)	(931)	(364)
Amortization of debt discount and issuance costs	(185)	(164)	(363)	(187)
Foreign exchange gain (loss)	(160)	5	(165)	(746)
Other income (expense)	1	107	(885)	(165)
Total other expense, net	(811)	(368)	(2,344)	(1,462)
Net loss before noncontrolling interest	(27,479)	(18,220)	(56,675)	(37,836)
Noncontrolling interest	80	209	274	441
Net loss	$ (27,399)	$ (18,011)	$ (56,401)	$ (37,395)
Basic and diluted net loss per common share	$ (0.19)	$ (0.17)	$ (0.39)	$ (0.35)
Shares used in calculation of basic and diluted net loss per common share	144,453	107,727	143,302	107,215