X0306 4 2017-02-23 0 0000891293 CTI BIOPHARMA CORP CTIC 0001382225 Telling Fred 3101 WESTERN AVENUE, SUITE 600 SEATTLE WA 98121 1 0 0 0 Stock Option (right to buy) 4.25 2017-02-23 4 A 0 50000 0.00 A 2027-02-22 Common Stock 50000 50000 D This stock option was granted on February 23, 2017 and vests on the first to occur of (i) the date that is twelve months after the date of grant, (ii) the first annual meeting of CTIC's shareholders in 2018 at which one or more members of the CTIC Board of Directors are to be elected, or (iii) immediately prior to the occurrence of a Change of Control (as such term is defined in CTIC's 2015 Equity Incentive Plan), subject to the Reporting Persons' continued service through such date or event. /s/ Louis A. Bianco, Attorney-in-fact for Fred Telling 2017-02-27