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Description of Business and Summary of Significant Accounting Policies - Additional Information (Details)
$ in Thousands, € in Millions, shares in Millions
3 Months Ended
Mar. 31, 2020
USD ($)
shares
Mar. 31, 2019
USD ($)
shares
Mar. 31, 2020
EUR (€)
Mar. 31, 2020
USD ($)
Dec. 31, 2019
EUR (€)
Dec. 31, 2019
USD ($)
Description Of Business And Significant Accounting Policies [Line Items]            
Accumulated deficit       $ 2,275,749   $ 2,263,563
Cash, cash equivalents, and short-term investments       81,100    
VAT receivable | €     € 3.9   € 3.9  
Provision for value added tax assessments $ 4,200          
Potential payment to tax authority     € 4.3 $ 4,800    
Equity-based compensation $ 1,167 $ 1,257        
Anti-dilutive securities excluded from computation of earnings per share (in shares) | shares 29.6 16.9        
Aequus Biopharma, Inc | Affiliated Entity            
Description Of Business And Significant Accounting Policies [Line Items]            
Interest in majority-owned subsidiary     60.00% 60.00%