Subsequent Events (Details) - Collaborative Arrangement Product Agreement - Servier - Subsequent Event € in Thousands	1 Months Ended
Feb. 28, 2019 EUR (€)
Subsequent Event [Line Items]
Reimbursement of contract costs	€ 620
Gain on contract termination	2,000
Extends Beyond May 31, 2019, Monthly Amount
Subsequent Event [Line Items]
Reimbursement of contract costs	50
Extends Beyond May 31, 2019
Subsequent Event [Line Items]
Reimbursement of contract costs	€ 200

The amount of early contract termination fees included in liabilities subject to compromise.

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 852
-SubTopic 10
-Section 55
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=84165509&loc=d3e56145-112766

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 852
-SubTopic 10
-Section 45
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=114872137&loc=d3e55717-112764

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 852
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6918054&loc=d3e56015-112765

Name:	us-gaap_LiabilitiesSubjectToCompromiseEarlyContractTerminationFees
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant