<?xml version="1.0" encoding="UTF-8"?>
<ns1:edgarSubmission xmlns:ns1="http://www.sec.gov/edgar/seventeenafiler" xmlns:com="http://www.sec.gov/edgar/common">
  <ns1:headerData>
    <ns1:submissionType>X-17A-5</ns1:submissionType>
    <ns1:filerInfo>
      <ns1:filer>
        <ns1:filerCredentials>
          <ns1:filerCik>0000891055</ns1:filerCik>
          <ns1:filerCcc>XXXXXXXX</ns1:filerCcc>
        </ns1:filerCredentials>
      </ns1:filer>
      <ns1:liveTestFlag>LIVE</ns1:liveTestFlag>
      <ns1:flags>
        <ns1:returnCopyFlag>false</ns1:returnCopyFlag>
        <ns1:confirmingCopyFlag>false</ns1:confirmingCopyFlag>
      </ns1:flags>
    </ns1:filerInfo>
  </ns1:headerData>
  <ns1:formData>
    <ns1:submissionInformation>
      <ns1:periodBegin>01-01-2021</ns1:periodBegin>
      <ns1:periodEnd>12-31-2021</ns1:periodEnd>
      <ns1:typeOfRegistrant>
        <ns1:typeOfBDRegistrant>Broker-dealer</ns1:typeOfBDRegistrant>
      </ns1:typeOfRegistrant>
      <ns1:materialWeakness>N</ns1:materialWeakness>
    </ns1:submissionInformation>
    <ns1:registrantIdentification>
      <ns1:brokerDealerName>HILLTOP SECURITIES INC.</ns1:brokerDealerName>
      <ns1:businessAddress>
        <com:street1>717 N. Harwood Street</com:street1>
        <com:street2>Suite 3400</com:street2>
        <com:city>Dallas</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>75201</com:zipCode>
      </ns1:businessAddress>
      <ns1:contactPersonName>Laura Leventhal</ns1:contactPersonName>
      <ns1:contactPersonPhoneNumber>214-859-1026</ns1:contactPersonPhoneNumber>
    </ns1:registrantIdentification>
    <ns1:accountantIdentification>
      <ns1:accountantName>PricewaterhouseCoopers, LLP</ns1:accountantName>
      <ns1:accountantAddress>
        <com:street1>212 N. Pearl Street</com:street1>
        <com:city>Dallas</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>75201</com:zipCode>
      </ns1:accountantAddress>
      <ns1:accountantType>Certified Public Accountant</ns1:accountantType>
    </ns1:accountantIdentification>
    <ns1:oathSignature>
      <ns1:signPersonName>M. Bradley Winges</ns1:signPersonName>
      <ns1:entityName>HILLTOP SECURITIES INC.</ns1:entityName>
      <ns1:signDate>12-31-2021</ns1:signDate>
      <ns1:signature>M. Bradley Winges</ns1:signature>
      <ns1:oathTitle>President and Chief Executive Officer</ns1:oathTitle>
      <ns1:confirmNotarizedFlag>Y</ns1:confirmNotarizedFlag>
    </ns1:oathSignature>
  </ns1:formData>
</ns1:edgarSubmission>
