Condensed Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012
Cash flows from operating activities:
Net loss	$ (21,272)	$ (6,532)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,871	799
Accretion of premium on marketable investment securities	1,962	1,550
Shares issued for payment of services	549	0
Non-cash interest expense	8,674	13,727
Non-cash royalties	(29,831)	(45,878)
Compensation expense on share-based awards	7,343	4,879
Realized gain on sale of marketable investment securities	(2)	(3)
(Increase) decrease in operating assets:
Accounts receivable	(4,041)	(14,865)
Inventory	6,118	0
Prepaid expenses, other current assets and other assets	528	3,182
(Decrease) increase in operating liabilities:
Accounts payable and accrued expenses	4,263	2,176
Other liabilities	(1,242)	(1,168)
Net cash used in operating activities	(25,080)	(42,133)
Cash flows from investing activities:
Sales of marketable investment securities	6,451	2,526
Maturities of marketable investment securities	58,251	76,914
Purchases of marketable investment securities	(114,738)	(67,668)
Acquisitions of property and equipment	(608)	(858)
Net cash (used in) provided by investing activities	(50,644)	10,914
Cash flows from financing activities:
Net proceeds from the sale of common stock	93,454	0
Net proceeds from the exercise of stock options	11,684	903
Shares withheld for the payment of taxes	(618)	0
Net cash provided by financing activities	104,520	903
Effect of exchange rate changes on cash	0	(13)
Net increase (decrease) in cash and cash equivalents	28,796	(30,329)
Cash and cash equivalents at beginning of period	17,471	82,401
Cash and cash equivalents at end of period	46,267	52,072
Supplemental Disclosures of Cash Flow Information
Cash paid for interest	712	714
Cash paid for income taxes	4	0
Supplemental Disclosure of Non-cash Investing and Financing Activities
6.1 million shares of NPS common stock issued in connection with the Takeda Termination and Transition agreement, see note 10	55,403	0
Unrealized gains on marketable investment securities	14	138
Accrued acquisition of property and equipment	69	45
Noncash reduction of debt	$ 20,245	$ 44,971