Condensed Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012
Cash flows from operating activities:
Net loss	$ (20,185)	$ (3,208)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,121	521
Accretion of premium (discount) on marketable investment securities	1,068	1,125
Shares issued for payment of services	549	0
Non-cash interest expense	5,955	9,524
Non-cash royalties	(19,784)	(34,561)
Compensation expense on share based awards	5,062	3,456
Realized gain on sale of marketable investment securities	(2)	(3)
(Increase) decrease in operating assets:
Accounts receivable	(4,108)	(40,731)
Inventory	6,573	0
Prepaid expenses, other current assets and other assets	460	2,120
(Decrease) increase in operating liabilities:
Accounts payable and accrued expenses	6,288	12,127
Other liabilities	(1,159)	(1,095)
Net cash used in operating activities	(18,162)	(50,725)
Cash flows from investing activities:
Sales of marketable investment securities	4,501	2,526
Maturities of marketable investment securities	42,156	54,056
Purchases of marketable investment securities	(74,888)	(57,453)
Acquisitions of property and equipment	(364)	(628)
Net cash used in investing activities	(28,595)	(1,499)
Cash flows from financing activities:
Net proceeds from the sale of common stock	93,454	0
Net proceeds from the exercise of stock options	6,585	512
Shares withheld for the payment of taxes	(574)	0
Net cash provided by financing activities	99,465	512
Effect of exchange rate changes on cash	9	(5)
Net increase (decrease) in cash and cash equivalents	52,717	(51,717)
Cash and cash equivalents at beginning of period	17,471	82,401
Cash and cash equivalents at end of period	70,188	30,684
Supplemental Disclosures of Cash Flow Information
Cash paid for interest	472	474
Cash paid for income taxes	0	0
Supplemental Disclosure of Non-cash Investing and Financing Activities
6.1 million shares of NPS common stock issued in connection with the Takeda Termination and Transition agreement, see note 10	55,403	0
Unrealized gains on marketable investment securities	75	101
Accrued acquisition of property and equipment	114	88
Noncash reduction of debt	$ 12,667	$ 37,247