Condensed Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Revenues
Royalties	$ 27,012	$ 24,483	$ 78,453	$ 70,244
Sale of royalty rights	0	0	25,000	0
Milestones and license fees	7	19	7	5,044
Product sales	0	99	0	99
Total revenues	27,019	24,601	103,460	75,387
Operating expenses
Cost of royalties	0	0	0	500
Cost of license fees	0	2	0	2,540
Research and development	17,957	20,227	70,797	52,267
General and administrative	8,329	6,413	25,769	17,028
Total operating expenses	26,286	26,642	96,566	72,335
Operating income (loss)	733	(2,041)	6,894	3,052
Other income (expense)
Interest income, net	64	70	224	260
Interest expense	(4,444)	(10,589)	(14,445)	(31,150)
Other	323	211	795	225
Total other expense, net	(4,057)	(10,308)	(13,426)	(30,665)
Loss before income tax expense	(3,324)	(12,349)	(6,532)	(27,613)
Income tax expense	0	0	0	18
Net loss	$ (3,324)	$ (12,349)	$ (6,532)	$ (27,631)
Net loss per common and potential common share
Basic	$ (0.04)	$ (0.14)	$ (0.08)	$ (0.35)
Diluted	$ (0.04)	$ (0.14)	$ (0.08)	$ (0.35)
Weighted average common and potential common shares outstanding
Basic shares	86,947	86,749	86,910	79,417
Diluted shares	86,947	86,749	86,910	79,417