Condensed Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011
Cash flows from operating activities:
Net loss	$ (3,208)	$ (15,282)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	521	169
Accretion of premium (discount) on marketable investment securities	1,125	691
Non-cash interest expense	9,524	7,895
Non-cash royalties	(34,561)	(7,996)
Compensation expense on share-based awards	3,456	2,024
Realized gain on sale of marketable investment securities	(3)	0
(Increase) decrease in operating assets:
Accounts receivable	(40,731)	(4,106)
Prepaid expenses, other current assets and other assets	2,120	(2,639)
(Decrease) increase in operating liabilities:
Accounts payable and accrued expenses	12,127	(4,095)
Other liabilities	(1,095)	(960)
Net cash used in operating activities	(50,725)	(24,299)
Cash flows from investing activities:
Sales of marketable investment securities	2,526	240
Maturities of marketable investment securities	54,056	38,031
Purchases of marketable investment securities	(57,453)	(47,041)
Acquisitions of property and equipment	(628)	(1,022)
Net cash used in investing activities	(1,499)	(9,792)
Cash flows from financing activities:
Principal payments on debt	0	(64,262)
Net proceeds from the sale of common stock and exercise of stock options	512	108,060
Decrease in restricted cash and cash equivalents	0	50,784
Net cash provided by financing activities	512	94,582
Effect of exchange rate changes on cash	(5)	(3)
Net (decrease) increase in cash and cash equivalents	(51,717)	60,488
Cash and cash equivalents at beginning of period	82,401	77,170
Cash and cash equivalents at end of period	30,684	137,658
Supplemental Disclosures of Cash Flow Information
Cash paid for interest	474	20,806
Cash paid for income taxes	0	0
Supplemental Disclosure of Non-cash Investing and Financing Activities
Unrealized gains on marketable investment securities	101	28
Accrued acquisition of property and equipment	88	128
Noncash reduction of debt	37,247	0
Accrued offering costs	0	129
Conversion of 5.75% convertible notes	$ 0	$ 33,260