425 1 d425.htm FILED PURSUANT TO RULE 425 Filed Pursuant to Rule 425

Filed Pursuant to Rule 425
Under the Securities Act of 1933
And Deemed Filed Pursuant to Rule 14a-12
Under the Securities Exchange Act of 1934

 Subject Company: NPS Pharmaceuticals, Inc.
Enzon Pharmaceuticals, Inc.
Commission File No. 000-23272

The following presentation was given by David Clark of NPS Pharmaceuticals, Inc. and Arthur Higgins of Enzon Pharmaceuticals, Inc. at the Banc of America Securities 2003 Healthcare Conference held in Las Vegas, NV on March 26, 2003.

 

 

Safe Harbor

Cautionary Statement For The Purpose Of The “Safe Harbor”
Provisions Of The Private Securities Litigation Reform Act Of 1995

This presentation contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. These statements are based on management’s current expectations and beliefs and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. The forward-looking statements contained in this presentation include statements about future financial and operating results and the proposed NPS/Enzon merger. These statements are not guarantees of future performance, involve certain risks, uncertainties and assumptions that are difficult to predict, and are based upon assumptions as to future events that may not prove accurate. Therefore, actual outcomes and results may differ materially from what is expressed herein. For example, if either of the companies do not receive required stockholder or governmental approvals or fail to satisfy other conditions to closing, the transaction will not be consummated. In any forward-looking statement in which NPS or Enzon expresses an expectation or belief as to future results, such expectation or belief is expressed in good faith and believed to have a reasonable basis, but there can be no assurance that the statement or expectation or belief will result or be achieved or accomplished. The following factors, among others, could cause actual results to differ materially from those described in the forward-looking statements: the risk that the NPS and Enzon businesses will not be integrated successfully; costs related to the proposed merger, failure of the NPS or Enzon stockholders to approve the proposed merger; and other economic, business, competitive and/or regulatory factors affecting NPS’ and Enzon’s businesses generally as set forth in NPS’s and Enzon’s filings with the SEC, including their Annual Reports on Form 10-K for their respective most recent fiscal years, especially in the Management’s Discussion and Analysis section, their most recent Quarterly Reports on Form 10-Q and their Current Reports on Form 8-K. NPS and Enzon are under no obligation to (and expressly disclaim any such obligation to) update or alter their forward-looking statements whether as a result of new information, future events or otherwise.

 

 

 

 

Safe Harbor continued

Additional Information And Where To Find It

In connection with the proposed NPS-Enzon merger, NPS, Enzon and Momentum Merger Corporation have caused to be filed a joint proxy statement/prospectus with the SEC in connection with the transaction described herein. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ THE JOINT PROXY STATEMENT/PROSPECTUS BECAUSE IT CONTAINS IMPORTANT INFORMATION ABOUT THE TRANSACTION DESCRIBED HEREIN. Investors and security holders may obtain a free copy of the joint proxy statement/prospectus and other documents filed by NPS and Enzon with the SEC at the SEC’s web site at http://www.sec.gov or by contacting NPS at 801-583-4939 and through NPS’ website at http://www.npsp.com, or by contacting Enzon at 908-541-8678 and through Enzon’s website at http://www.enzon.com.

NPS and its directors and executive officers may be deemed to be participants in the solicitation of proxies from the stockholders of NPS and Enzon in connection with the transaction described herein. Information regarding the special interests of these directors and executive officers in the transaction described is included in the joint proxy statement/prospectus described above. Additional information regarding these directors and executive officers is also included in NPS’ 2002 Annual Report on Form 10-K, which was filed with the SEC on March 21, 2003. This document is available free of charge at the SEC’s web site at http://www.sec.gov or by contacting NPS at 801-583-4939 and through NPS’ website at http://www.npsp.com.

Enzon and its directors and executive officers also may be deemed to be participants in the solicitation of proxies from the stockholders of Enzon and NPS in connection with the transaction described herein. Information regarding the special interests of these directors and executive officers in the transaction described herein is included in the joint proxy statement/prospectus described above. Additional information regarding these directors and executive officers is also included in Enzon’s proxy statement for its 2002 Annual Meeting of Stockholders, which was filed with the SEC on or about October 28, 2002. This document is available free of charge at the SEC’s web site at http://www.sec.gov or by contacting Enzon at 908-541-8678 and through Enzon’s website at http://www.enzon.com.

 

  

   

 

Our Mutual Goal

   
         
    To Build a Sustainable Top-Tier Biotech Based On:    
           
    • A deep, diversified and sustainable pipeline

   
    • A clearly defined pathway to profitability

   
    • A fully integrated infrastructure and stable financial position

    
         


Synergies Expand and Accelerate
Value Creation

 
•
Expand pipeline development
— e.g., CNS product opportunities
 
•
Accelerate program development
— e.g., ALX-0600 for multiple indications
 
•
Leverage financial strength and commercial capacity
— e.g., in-license products and technologies, and optimize PREOS
    partnership


The Merger Creates a Top-Tier Biotech
 
•
Management with a proven record of building businesses
 
•
Drug discovery and development expertise
 
•
Manufacturing capacity and experience
 
•
Commercial infrastructure
 
•
Strong, dependable revenues


Post Merger Strengths
•
Fully Integrated:
— From drug discovery through manufacturing and commercialization
•
Innovative and robust pipeline:
— ~$150M R&D budget *
— Phase III: 2 programs

— Phase II: 3 programs

— >10 early stage programs

— Multiple platform technologies
* Based upon 2003 pro-forma financials       


Post-Merger Metrics
   
Comparable Company Analysis(a)
   
         
2003 Est.
Products
     
     
Company
Market Value
Revenue
R&D
Marketed
   Phase III
     
 
 
      Millennium   $2,152.2
$402.5
$496.5
2
--
     
      Celgene   $1,942.9
$171.0
$  89.8
1
1
     
      Amylin   $1,334.2
$  49.4
$111.8
0
1
     
      Neurocrine   $1,297.1
$  92.0
$110.5
0
1
     
      ICOS   $1,055.7
$105.5
$157.5
1
1
     
           
      Enzon/NPS
~$200.0
>$150.0
5
2
     
      (a) Projected Financial Information as per Wall Street equity research and calendarized to reflect 12/31 year end      
                       

Product Pipeline & Marketed Products
         
         
 
Product 		  Preclinical/
  Research 		Phase I Phase II Phase III Marketed   Partner
 
  PEG-INTRON
  Schering-Plough   
  ABELCET
  Proprietary
  ADAGEN
  Proprietary
  ONCASPAR   Proprietary
  DEPOCYT
  Proprietary
  Cinacalcet HCl
    Amgen/Kirin
  PREOS
    Proprietary
  PROTHECAN
    Proprietary
  ALX-0600
    Proprietary
  Cinacalcet HCl
    Amgen/Kirin
  NPS 1776
    Proprietary
  NPS 1506
    Proprietary
  Calcilytics
    GSK
  PEG-Cytotoxics
    Proprietary
  Gly-T Inhibitors
    Janssen
  mGluRs     AstraZeneca
  SCA’s
    Micromet
  Inhaled Leuprolide
     Nektar
                 
    = Enzon  = NPS      


5 Marketed Products


 
•
  PEG-INTRON ®


 
•
  ABELCET ®
 
•
  ONCASPAR ®
 
•
  DEPOCYT ®
 
•
  ADAGEN ®


2 Phase III Clinical Products
    
   
PREOSTM
Cinacalcet HCI
   


Combined Management Team Includes:
  Hunter Jackson, Ph.D. (NPS)
          Executive Chairman of the Board

Arthur J. Higgins (Enzon)
          Chief Executive Officer

Ulrich Grau, Ph.D. (Enzon)
          Executive Vice President, Research and Development

Kenneth J. Zuerblis (Enzon)
          Executive Vice President, Finance, Chief Financial Officer
               and Secretary

Thomas B. Marriot, Ph.D. (NPS)
          Executive Vice President, Development

David L. Clark (NPS)
          Executive Vice President, Corporate Communications
               and Investor Relations
 
 
 
 


Selected Pro-Forma Financials
Pro-Forma Operating Summary (US$ in millions)
Year Ending December 31, 2002 Pro Forma 2002
Product Revenues:  
      Sales $   31.5
      Royalties $   82.6
$ 114.1 * 
         
  *(Current estimated annualized revenues = $200.0)
   
Expenses:  
      SG&A $   48.0
      R&D $ 102.0
   
Long-Term Convertible Debt $ 400.0
Ending Cash Balance


 $ 380.0


Expected Milestones and News Flow

               
 
Type
 
2003
  2004
         
  Clinical Data  

        Phase III Cinacalcet HCl data in secondary HPT

  Regulatory  

              File Cinacalcet HCI NDA

  Clinical Data  

                    PREOS 2-year rat toxicology study data

  Clinical Data                       PREOS TOP Study completed
  Clinical Data                       Phase IIa results from PROTHECAN
  Clinical Data                       Initiate additional PII/III ALX-0600 (SBS)
  Market Data                             HCV maintenance studies
  Regulatory                                   File PREOS NDA
  Regulatory  
                                Prothecan Phase III program 
  Clinical Data  
                                         Cinacalcet HCI approval 
          = NPS      = Enzon       
                 


2007... Where We’re Going
                          
•
Revenue > $500M
 
•
Strong, balanced clinical pipeline
 
•
R&D budget > $180M
 
•
EBITDA > $100M
 
•
Industry leading growth rate
 
•
Cash > $500M