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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2025
Share-Based Payment Arrangement [Abstract]  
Schedule of non-cash stock-based compensation expense
Non-cash stock-based compensation expense (service-based stock options, restricted stock units and employee stock purchase plan) is summarized in the following table: 
 Years Ended December 31,
(in thousands)202520242023
Cost of product sales$4,217 $3,911 $2,970 
Research and development4,680 4,068 3,705 
Selling, general and administrative29,870 28,516 25,650 
Total non-cash stock-based compensation expense$38,767 $36,495 $32,325 
Schedule of fair value assumptions
The fair value of each service-based stock option grant for the reported periods is estimated on the date of the grant using the Black-Scholes option-pricing model using the assumptions noted in the following table:
 Year Ended December 31,
Service-Based Stock Options202520242023
Expected dividend rate—%—%—%
Expected stock price volatility
54.2 - 58.2%
57.3 - 62.5%
62.5 - 66.7%
Risk-free interest rate
3.6 - 4.5%
3.4 - 4.7%
3.40 -4.7%
Expected life (years)5.35.55.5
Weighted-average grant date fair value$28.18$28.05$18.85
Schedule of activity for service-based stock options
The following table summarizes the activity for service-based stock options for the indicated periods: 
Service-Based Stock OptionsOptions
Weighted-Average
 Exercise Price
Weighted-Average
 Remaining
 Contractual Term
(Years)
Aggregate
 Intrinsic
 Value
(Thousands)
Outstanding at December 31, 20245,764,107 $31.22 6.1$137,365 
Granted620,373 51.34 
Exercised(675,645)18.48 
Expired(81,074)36.84 
Forfeited(85,220)35.29 
Outstanding at December 31, 20255,542,541 $34.88 5.7$42,291 
Exercisable at December 31, 20254,439,220 $32.09 5.0$41,007 
Schedule of activity for restricted stock awards
The following table summarizes the activity for restricted stock units for the indicated periods: 
Restricted Stock UnitsNumber of Restricted Stock UnitsWeighted-Average Grant Date Fair Value
Outstanding at December 31, 20241,135,261 $40.80 
Granted607,991 50.48 
Vested(401,140)40.78 
Forfeited(158,117)45.41 
Unvested at December 31, 20251,183,995 $45.17