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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2024
Share-Based Payment Arrangement [Abstract]  
Schedule of non-cash stock-based compensation expense
Non-cash stock-based compensation expense (service-based stock options, restricted stock units and employee stock purchase plan) is summarized in the following table: 
 Years Ended December 31,
(in thousands)202420232022
Cost of product sales$3,911 $2,970 $3,630 
Research and development4,068 3,705 5,261 
Selling, general and administrative28,516 25,650 28,292 
Total non-cash stock-based compensation expense$36,495 $32,325 $37,183 
Schedule of fair value assumptions
The fair value of each service-based stock option grant for the reported periods is estimated on the date of the grant using the Black-Scholes option-pricing model using the assumptions noted in the following table:
 Year Ended December 31,
Service-Based Stock Options202420232022
Expected dividend rate—%—%—%
Expected stock price volatility
57.3 - 62.5%
62.5 - 66.7%
63.8 - 75.3%
Risk-free interest rate
3.4 - 4.7%
3.4 - 4.7%
1.50 -4.4%
Expected life (years)5.55.5
5.3 - 6.3
Weighted-average grant date fair value$28.05$18.85$19.83
Summary of activity for service-based stock options
The following table summarizes the activity for service-based stock options for the indicated periods: 
Service-Based Stock OptionsOptions
Weighted-Average
 Exercise Price
Weighted-Average
 Remaining
 Contractual Term
(Years)
Aggregate
 Intrinsic
 Value
(Thousands)
Outstanding at December 31, 20236,716,686 $25.85 6.2$88,387 
Granted767,037 48.49 
Exercised(1,544,653)14.97 
Expired(28,247)53.73 
Forfeited(146,716)42.44 
Outstanding at December 31, 20245,764,107 $31.22 6.1$137,365 
Exercisable at December 31, 20244,381,393 $28.38 5.4$116,951 
Summary of activity for restricted stock awards
The following table summarizes the activity for restricted stock units for the indicated periods: 
Restricted Stock UnitsNumber of Restricted Stock UnitsWeighted-Average Grant Date Fair Value
Outstanding at December 31, 2023930,936 $32.85 
Granted644,905 48.20 
Vested(323,435)32.90 
Forfeited(117,145)40.18 
Unvested at December 31, 20241,135,261 $40.80