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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2023
Share-Based Payment Arrangement [Abstract]  
Schedule of non-cash stock-based compensation expense Non-cash stock-based compensation expense (service-based stock options, restricted stock units and employee stock purchase plan) is summarized in the following table:
 Three Months Ended September 30,Nine Months Ended September 30,
(in thousands)2023202220232022
Cost of product sales$660 $840 $2,341 $2,992 
Research and development892 1,273 2,862 4,143 
Selling, general and administrative6,372 6,991 20,213 22,308 
Total non-cash stock-based compensation expense$7,924 $9,104 $25,416 $29,443