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Stock-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2023
Share-Based Payment Arrangement [Abstract]  
Schedule of non-cash stock-based compensation expense
Non-cash stock-based compensation expense (service-based stock options, restricted stock units and employee stock purchase plan) is summarized in the following table:
 Three Months Ended March 31,
(in thousands)20232022
Cost of product sales$885 $1,118 
Research and development977 1,350 
Selling, general and administrative6,869 7,063 
Total non-cash stock-based compensation expense$8,731 $9,531