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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of non-cash stock-based compensation expense
Non-cash stock-based compensation expense (service-based stock options, restricted stock units and employee stock purchase plan) is summarized in the following table:
 Three Months Ended September 30,Nine Months Ended September 30,
(in thousands)2022202120222021
Cost of product sales$840 $1,114 $2,992 $3,313 
Research and development1,273 1,126 4,143 3,222 
Selling, general and administrative6,991 6,356 22,308 19,946 
Total non-cash stock-based compensation expense$9,104 $8,596 $29,443 $26,481