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Stock-Based Compensation (Tables)
 3 Months Ended
Mar. 31, 2022
Share-based Payment Arrangement [Abstract]  
Schedule of Non-cash Stock-based Compensation Expense
Non-cash stock-based compensation expense (service-based stock options, restricted stock units and employee stock purchase plan) is summarized in the following table:
 Three Months Ended March 31,
(in thousands)20222021
Cost of product sales$1,118 $911 
Research and development1,350 863 
Selling, general and administrative7,063 5,245 
Total non-cash stock-based compensation expense$9,531 $7,019