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Stock-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of non-cash stock-based compensation expense
Non-cash stock-based compensation expense (employee stock purchase plan, service-based stock options and restricted stock units) included in cost of product sales, research and development expenses and selling, general and administrative expenses is summarized in the following table: 
 Three Months Ended September 30,Nine Months Ended September 30,
(in thousands)2021202020212020
Cost of product sales$1,114 $481 $3,313 $1,541 
Research and development1,126 458 3,222 1,455 
Selling, general and administrative6,356 1,736 19,946 7,823 
Total non-cash stock-based compensation expense$8,596 $2,675 $26,481 $10,819