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Revenue (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 21, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
CONCENTRATION        
Warrants issued in connection with debt arrangement   $ 0 $ 207 $ 190
Carticel and MACI | Customer concentration | Revenue Concentration        
CONCENTRATION        
Concentration risk   16.00% 35.00% 31.00%
Carticel and MACI | Customer concentration | Accounts Receivable Concentration        
CONCENTRATION        
Concentration risk   2.00% 46.00%  
Epicel | Customer concentration | Revenue Concentration        
CONCENTRATION        
Concentration risk   7.00% 10.00% 11.00%
Epicel | Customer concentration | Accounts Receivable Concentration        
CONCENTRATION        
Concentration risk   4.00% 3.00%  
Potential Payment        
CONCENTRATION        
Other Commitment   $ 1,300 $ 1,200  
ICT        
CONCENTRATION        
License Agreement, Initial Payment $ 5,200      
ICT | Potential Payment        
CONCENTRATION        
Other Commitment 1,200      
December 21, 2017 Warrants | ICT        
CONCENTRATION        
Warrants issued in connection with debt arrangement $ 4,000