Stock Option Plans, Shares Reserved and Warrants (Details) - $ / shares	6 Months Ended	12 Months Ended
	Jun. 30, 2017	Dec. 31, 2016
Weighted average remaining contractual life
Balance		7 years 11 months 23 days
2009 Equity Incentive Plan [Member]
Number of options
Outstanding options, beginning	4,320,409
Options granted	2,221,750
Options excercised	(833)
Options canceled/expired	(141,677)
Outstanding options, ending	6,399,649	4,320,409
Exercisable options	2,966,509	2,319,963
Weighted average exercise price
Outstanding options, beginning	$ 6.06
Options granted	3.26
Options exercised	3.35
Options canceled/expired	6.35
Outstanding options, ending	5.09	$ 6.06
Exercisable options	$ 5.65
Weighted average remaining contractual life
Balance	8 years 4 months 24 days
Options granted	9 years 8 months 5 days
Exercisable	7 years 4 months 10 days