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CONDENSED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Cash flows from operating activities:    
Net loss $ (27,824) $ (16,355)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 48 27
Accretion and amortization on investments, net 416 (124)
Amortization of debt issuance costs/debt discount 180  
Gain on sales of equity investment (1,233)  
Change in fair value of equity investment, including foreign currency translation   220
Stock-based compensation for services by non-employees 25 16
Stock-based compensation for employees and directors 1,794 1,568
Amortization of right-of-use assets 132 244
Changes in assets and liabilities:    
Current and noncurrent assets (3,757) 249
Current and noncurrent liabilities (2,515) (12,039)
Net cash used in operating activities (32,734) (26,194)
Cash flows from investing activities:    
Purchases of property and equipment (10) (191)
Purchases of marketable securities (25,122) (6,913)
Proceeds from maturities of marketable securities 61,621 39,262
Proceeds from sales of equity investment 1,594  
Net cash provided by investing activities 38,083 32,158
Cash flows from financing activities:    
Proceeds from issuances of common stock from equity plans 17  
Proceeds from issuances of common stock from at market offerings, net of paid issuance costs 16,234 686
Proceeds from exercise of warrants 12  
Net cash provided by financing activities 16,263 686
Net increase in cash, cash equivalents and restricted cash 21,612 6,650
Cash, cash equivalents and restricted cash at the beginning of the period 10,288 13,914
Cash, cash equivalents and restricted cash at the end of the period $ 31,900 $ 20,564