STOCKHOLDERS' EQUITY (Tables)

12 Months Ended

Dec. 31, 2012

STOCKHOLDERS' EQUITY

Schedule of warrants outstanding to purchase common stock and classified as equity

Issuance Date	Exercise Price		Number of Shares		Exercisable Date	Expiration Date
November 2011	$	2.32		461,382	November 2011	November 2021
August 2011	$	3.98		537,893	August 2011	August 2021
September 2009	$	9.00		150,000	September 2009	September 2014
April 2005	$	3.75		470,000	April 2005	April 2015
				1,619,275

Schedule of aggregate option and award activity

				Outstanding Options
	Shares Available For Grant			Number of Shares			Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Life (In years)		Aggregate Intrinsic Value (In thousands)
Balance at December 31, 2011		14,473,498			14,355,548		$	5.51			$	1
Options granted		(7,532,500	)		7,532,500		$	1.51
Awards granted		(79,679	)		—		$	—
Options exercised		—			(417	)	$	1.41
Options canceled/forfeited		4,076,125			(4,076,125	)	$	4.50
Awards canceled/forfeited		2,620,327			—		$	—
Balance at December 31, 2012		13,557,771			17,811,506		$	4.05		5.82	$	2
Options exercisable at December 31, 2012					10,410,194		$	5.49		3.45	$	—
Options fully vested and expected to vest at December 31, 2012					17,160,377		$	4.13		5.69	$	2

Schedule of information about stock options outstanding by exercise price range

	Options Outstanding
Exercise Price Range	Number of Shares		Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Life (In years)
$1.33 - $1.37		27,000	$	1.35		9.48
$1.41 - $1.41		4,664,229	$	1.41		9.34
$1.42 - $3.98		4,478,988	$	2.51		6.85
$4.30 - $11.07		8,641,289	$	6.28		3.37
$1.33 - $11.07		17,811,506	$	4.05		5.82

Schedule of aggregate restricted stock activity

	Number of Shares			Weighted Average Grant Date Fair Value Per Share		Weighted Average Remaining Contractual Term (In years)
Non-vested restricted stock at December 31, 2011		6,102,385		$	4.28		1.70
Granted		79,679		$	1.46
Vested		(643,775	)	$	4.55
Canceled/forfeited		(2,620,327	)	$	4.35
Non-vested restricted stock at December 31, 2012(1)		2,917,962		$	4.08		0.90

(1)

Includes 1,663,000 performance-based restricted stock awards that have not achieved certain strategic goals and 714,000 market-based restricted stock awards that have not achieved certain market price thresholds.

Summary of allocation of stock-based compensation expense related to share-based payment awards

	Year Ended December 31,
	2012		2011		2010
	(In thousands)
Research and development	$	2,336	$	5,799	$	6,625
Restructuring charges		107		174		—
General and administrative		2,868		9,276		7,093
Stock-based compensation expense included in operating expenses	$	5,311	$	15,249	$	13,718

Schedule of assumptions used to estimate the fair value of options granted

	2012	2011	2010
Dividend yield	0%	0%	0%
Expected volatility range	0.631 to 0.740	0.629 to 0.660	0.625 to 0.635
Risk-free interest rate range	0.81% to 1.25%	0.88% to 2.37%	1.11% to 2.65%
Expected term	6 yrs	5 yrs	5 yrs

Schedule of assumptions used to estimate the fair value of employee stock purchases under the Purchase Plan

	2012	2011	2010
Dividend yield	0%	0%	0%
Expected volatility range	0.458 to 0.774	0.278 to 0.584	0.468 to 0.995
Risk-free interest rate range	0.06% to 0.21%	0.10% to 0.32%	0.18% to 0.54%
Expected term range	6 mos to 12 mos	6 mos to 12 mos	6 mos to 12 mos

Schedule of common stock reserved for future issuance

Outstanding stock options	17,811,506
Options and awards available for grant	13,557,771
Employee stock purchase plan	356,390
Warrants outstanding	1,619,275
Total	33,344,942