X0609 4 2026-03-02 0 0000886163 LIGAND PHARMACEUTICALS INC LGND 0001905248 Espinoza Octavio false 555 HERITAGE DRIVE SUITE 200 JUPITER FL 33458 0 1 0 0 Chief Financial Officer 0 Common Stock 2026-03-02 4 A 0 4933 0 A 37945 D Employee Stock Option (right to buy) 202.55 2026-03-02 4 A 0 23527 0 A 2036-03-02 Common Stock 23527 23527 D Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock. The RSUs shall vest over three years, in three substantially equal annual installments on February 15, 2027; February 15, 2028; and February 15, 2029, subject to the Reporting Person's continued service to the Issuer through each such vesting date. Pursuant to an election under the Issuer's Nonqualified Deferred Compensation Plan, delivery of shares otherwise issuable upon each vesting date will be deferred. The Stock Option grant vests and is exercisable as to 12.5% of the underlying shares 6 months after the grant date, and in 42 substantially equal monthly installments thereafter. By: /s/ Andrew Reardon, Attorney-in-Fact For: Octavio Espinoza 2026-03-27