144 0001223000 XXXXXXXX LIVE 0000886163 LIGAND PHARMACEUTICALS INC 001-33093 3911 SORRENTO VALLEY BLVD SUITE 110 SAN DIEGO CA 92121 858-550-7500 KOZARICH JOHN W Director Common UBS Financial Services, Inc.

Eleven Madison Avenue 4th Floor New York NY 10010

467 107349.29 19941141 05/01/2026 Nasdaq Common 04/24/2024 Various Issuer N 467 04/24/2024 NA N John Kozarich

3911 Sorrentino Valley Blvd. Suite 110 San Diego CA 92121

Common 02/02/2026 467 91490.02 John Kozarich

3911 Sorrentino Valley Boulevard Suite 110 San Diego CA 92121

Common 03/02/2026 467 93632.38 John Kozarich

3911 Sorrentino Valley Blvd Suite 110 San Diego CA 92121

Common 04/01/2026 467 94440.10 05/01/2026 03/07/2025 /s/ UBS Financial Services Inc, as attorney-in-fact for John Kozarich