X0306 4 2022-12-22 0 0000886163 LIGAND PHARMACEUTICALS INC LGND 0001649903 Korenberg Matthew E 3911 SORRENTO VALLEY BOULEVARD, SUITE 110 SAN DIEGO CA 92121 0 1 0 0 President & COO Employee Stock Option (right to buy) 67.03 2022-12-22 4 A 0 25967 0.00 A 2032-12-22 Common Stock 25967 25967 D Grant to reporting person of stock options that will vest and become exercisable over a 4-year period measured from the date of grant, with 12-1/2% of the shares subject to the stock options vesting on the date that is six months after the date of grant and the remaining stock options vesting in 42 equal monthly installments thereafter. /s/ Andrew Reardon, Attorney-in-Fact for Matthew E. Korenberg 2022-12-27