X0306 4 2022-02-15 0 0000886163 LIGAND PHARMACEUTICALS INC LGND 0001649903 Korenberg Matthew E 5980 HORTON STREET, SUITE 405 EMERYVILLE CA 94608 0 1 0 0 EVP,Finance & Strategy and CFO Common Stock 2022-02-15 4 F 0 906 123.68 D 46807 D Common Stock 2022-02-15 4 F 0 969 123.68 D 45838 D Common Stock 2022-02-15 4 F 0 1532 123.68 D 44306 D Represents shares withheld to satisfy tax withholding obligations upon the vesting of previously reported restricted stock units that were granted on 02/11/2019. Represents shares withheld to satisfy tax withholding obligations upon the vesting of previously reported restricted stock units that were granted on 02/13/2020. Represents shares withheld to satisfy tax withholding obligations upon the vesting of previously reported restricted stock units that were granted on 02/03/2021. By: Charles S. Berkman For: Matthew E. Korenberg 2022-02-16