R. Randall Wang
Partner

Direct: 314-259-2149
rrwang@bryancave.com

June 7, 2010

VIA EDGAR

Mr. Jim B. Rosenberg

Senior Assistant Chief Accountant

Division of Corporate Finance

Securities and Exchange Commission

100 F. Street, NE

Washington, D.C. 20549

Re:       Express Scripts, Inc.

            Form 10-K for the fiscal year ended December 31, 2009

            Form 8-K filed February 24, 2010

            Schedule 14A filed March 24, 2010

            File No. 000-20199

Dear Mr. Rosenberg:

On behalf of Express Scripts, Inc. (the “Company”), and as discussed with

Ms. Laura Crotty, I am writing to confirm that the Company intends to respond

to the comments contained in the letter from the SEC staff to the Company dated

May 25, 2010 by Monday, June 14, 2010.

Please do not hesitate to contact me at (314) 259-2149 should you have any questions

regarding this matter.

Very truly yours,

/s/ R. Randall Wang

R. Randall Wang

cc:        Sasha Parikh, Staff Accountant

            Mark Brunhofer, Review Accountant

            Laura Crotty, Staff Attorney

            Express Scripts, Inc.

                 Keith J. Ebling