EXHIBIT 12.1

EXPRESS SCRIPTS, INC.
Calculation of Ratio of Earnings to Fixed Charges
(Dollar amounts in millions)

	Three Months Ended
	March 31,
	2011		2010
Income from continuing operations before income taxes	$	513.1	$	413.6
Add:
Interest expense		39.7		42.8
Estimated interest component of rental expense		2.3		3.1
Income as adjusted	$	555.1	$	459.5
Fixed charges:
Interest expense		39.7		42.8
Estimated interest component of rental expense		2.3		3.1
Total fixed charges	$	42.0	$	45.9
Ratio of Earnings to Fixed Charges		13.2		10.0

Note: Interest component of rental expense estimated to be 1/3 of rental expense, which management believes represents a reasonable approximation of the interest factor.